News

IntensiChem at NEPIC Meet the Members 2015

Eager to discuss the value that continuous processing and flow chemistry can bring UK industry, IntensiChem will be at the NEPIC Members meeting. Surely to be a great event, this cluster meeting will have hundreds of companies involved in the process industry supply chain all hopefully creating new business.

 

Selective Hydrogenation of Artemisinic Acid to Dihydroartemisinic Acid

October 28th 2013

Working with CHAI (Clinton Health Access Initiative), IntensiChem successfully hydrogenated artemisinic acid to dihydroartemisinic acid (DHAA) using their proprietary in-house, high performance, flow hydrogenation system.
Furthermore, this delivered the desired diastereoselectivity of >95% at >99% conversion with a residence time of <20 seconds, using a base metal catalyst in a fixed bed.

 

 

In over 25 years, an economic and desirable hydrogenation of artemisinic acid has not been presented and compromised alternatives had to be implemented.
These unoptimised conditions outperformed previous research reported in the field using platinum group catalysts, expensive ligands or stoichiometric metal reductants.

 IntensiChem win TSB grant to develop innovative flow ozonolysis

 

March 7th 2013

 

IntensiChem have won UK Technology Strategy Board feasibility funding from the Innovation in Manufacturing Competences competition. With collaboration partner Asynt, the project will aim to develop a true single pass, flow ozonolysis technology applicable from laboratory to commercial production. Asynt aim to support the development of novel products central to the laboratory.

 

Ozonolysis uses ozone, generated from low cost oxygen as needed, to cleave or oxidise chemical bonds cleanly during chemical processing. By using ozone rather than traditional metal based oxidants or organic peroxides, both yield and quality are increased whilst waste is reduced.

 

Currently, ozone is rarely used for industrial chemical processes. When ozone is used by manufacturers, contract or otherwise, batch reactors are utilised the majority of the time, meaning the processes are more prone to explosion. Due to this risk, its use is engineered out quite early in fine chemical processes, such as for pharmaceuticals.

 

There are few commercial flow ozonolysis systems currently available. They are either, not scalable for industry and confined to the laboratory or utilise a recycle (or Buss) loop technique, which is a compromise and reduces, but doesn’t eliminate issues with build-up of explosive ozonides.

 

The intended project is to develop a single pass, flow ozonolysis concept that, through its design can be scaled to react substrates with ozone, for commercial processes, extremely quickly. The single pass approach also minimises accumulation of potentially explosive peroxides or ozonides by introducing a quench in flow, which is easier to control and delivers product more safely.

 

The part funded proof of concept project is to be carried out from March for four months, culminating in a showcase of results in July.

 

The Technology Strategy Board facilitates and supports innovation in UK businesses, funded by the UK Government, with a 2012-13 budget of £390m.

 

For further information about this or other flow technologies, please contact us.

 

 

 

IntensiChem at NEPIC Meet the Members 2015